TABLE 1

Expected deuterium isotope effects produced by different kinetic mechanisms on nondeuterium abstraction pathways

In this study, nondeuterium abstraction pathways include the formation of TB, TP, and TMU. Values are from Gillette et al. (1994).

Type of Experiment
Magnitude of DV/K
Nondissociative Mechanism
Dissociative Mechanism
Parallel Mechanism
Competitive <1.0a 1.0 1.0
Noncompetitive
<1.0
<1 to >1
1.0

  • ↵ a An isotope effect of 1.0 indicates no effect. An inverse isotope effect is <1. A normal isotope effect is >1.