TABLE 1

Correlation coefficients between trans-3′-hydroxycotinine O- and N-glucuronidations and other glucuronidations in microsomes from 13 human livers

Glucuronidation	Substrate Concentration	Trans-3′-Hydroxycotinine O-Glucuronidation			Trans-3′-Hydroxycotinine N-Glucuronidation
Glucuronidation	Substrate Concentration			r	p	r	p
	μM
Trans-3′-hydroxycotinine N-glucuronidation	1000	0.435	NS
Nicotine N-glucuronidation	50	0.032	NS	0.918	<0.0001
Cotinine N-glucuronidation	200	0.055	NS	0.852	<0.001
Imipramine N-glucuronidation	500	0.122	NS	0.502	NS
Propofol glucuronidation	30	0.245	NS	0.032	NS
Morphine 3-glucuronidation	250	0.603	NS	0.798	<0.01
Valproic acid glucuronidation	1000	0.716	<0.01	0.372	NS

NS, not significant.