TABLE 1

Genetic polymorphism in the BCRP gene in Japanese placentas (n = 100)

Location	Position^a	Reference Allele^b	Variant Allele	Amino Acid Substitution	Genotype					Frequency of Variant Allele
Location	Position^a	Reference Allele^b	Variant Allele	Amino Acid Substitution						Frequency of Variant Allele	R/R	R/V	V/V
5′-Flanking region	-20445	gtctCctcc	gtctTctcc		98	2	0	0.010
	-20296	agctAttaa	agctGttaa		80	18	2	0.110
	-19781	aaaaAttat	aaaaGttat		99	1	0
	-19572_-19569	ctcaCTCAcaaa	ctca—caaa		60	33	7	0.235
Exon 2	34	cccaGtgtc	cccaAtgtc	Val12Met	70	24	6	0.180
Intron 2	203 + 16	tttaAttta	tttaGttta		70	24	6	0.180
Intron 3	263 + 10	tataAgaga	tataGgaga		85	14	1	0.080
	263 + 72	ttttGtgtg	ttttTGtgtg		99	1	0	0.005
Exon 4	376	ggtaCaagt	ggtaTaagt	Gln126stop	98	2	0	0.010
Exon 5	421	cttaCagtt	cttaAagtt	Gln141Lys	42	45	13	0.355
Intron 5	532-16	ttatAatat	ttatGatat		99	1	0	0.005
Exon 9	1098	aggaGatca	aggaAatca	Synonymous	98	2	0	0.010
Intron 10	1277 + 95	atagTgtaa	atagAgtaa		97	3	0	0.015
Exon 11	1322	agcaGtgtt	agcaAtgtt	Ser441Asn	99	1	0	0.005
Intron 11	1367 + 20	ttctAggaa	ttctGggaa		71	25	4	0.165
Exon 12	1465	tataTttac	tataCttac	Phe489Leu	99	1	0	0.005
Intron 12	1492 + 49	ctatGggtg	ctatCggtg		44	45	11	0.335
Exon 13	1515	atgcCttct	atgc-ttct	Phe506Ser	99	1	0	0.005
				Phe507Leu
				Val508Leu
				Met509stop
Intron 13	1648-42	tgaaAttac	tgaaTttac		99	1	0	0.005
	1648-21	gactCttag	gactTttag		71	25	4	0.165
Intron 14	1738-46	tcttAaaat	tcttGaaat		24	52	24	0.500
3′-UTR	2332	cttcAgtct	cttcTAgtct		86	14	0	0.070
	2364	tgccAttat	tgccCttat		99	1	0	0.005
	2512	agaaCttac	agaaTttac		99	1	0	0.005

R, reference allele; V, variant allele.
↵ a Position is in respect to the translation start site of the BCRP gene; the A in ATG is + 1 and the base immediately 5′ is -1.
↵ b Reference allele: GenBank/EMBL accession no. AC084732.