TABLE 2

Frequencies of BCRP alleles in different ethnic populations

Values in parentheses indicate 95% confidence intervals.


SNP

Amino Acid Change

Population

Genotype

Frequency of Variant Allele
R/R
R/V
V/V
G34A Val12Met Japanese (n = 120) 81 37 2 0.17 (0.12-0.22)
Caucasian (n = 150) 139 11 0 0.04 (0.02-0.06)
African American (n = 150) 132 17 1 0.06 (0.04-0.09)
C376T Gln126stop Japanese (n = 120) 118 2 0 0.01 (0.00-0.02)
Caucasian (n = 150) 150 0 0 0.00
African American (n = 150) 150 0 0 0.00
C421A Gln141Lys Japanese (n = 120) 61 45 14 0.30 (0.25-0.36)
Caucasian (n = 150) 121 25 4 0.11 (0.08-0.15)


African American (n = 150)
144
5
1
0.02 (0.01-0.04)
  • R, reference allele; V, variant allele.