No. | Compound Name | Control (HEK Cells) | Mean UGT1A7 | Mean UGT1A8 | |
---|---|---|---|---|---|
activity ± S.E. | |||||
1 | 10-OH BaP | N.D. | +++ | +++ | |
2 | 5-OH BaP | N.D. | +++ | +++ | |
3 | 12-OH BaP | 0.04, 0.01 | +++ | +++ | |
4 | 7-OH BaP | N.D. | +++ | 2.08 ± 0.15 | |
5 | 11-OH BaP | N.D. | +++ | 1.33 ± 0.08 | |
6 | 1-Naphthol | 0.07, 0.004, 0.006 | +++ | 1.28 ± 0.12 | |
7 | 1-OH BaP | N.D. | +++ | 1.00 ± 0.04 | |
8 | 4-OH BaP | N.D. | +++ | 0.90 ± 0.23 | |
9 | 6-OH BaP | N.D. | 0.45 ± 0.03 | 0.79 ± 0.26 | |
10 | 4-Methylumbelliferone | N.D. | +++ | 0.64 ± 0.01 | |
11 | 7-OH coumarin | N.D. | +++ | 0.64 ± 0.01 | |
12 | Chrysin | N.D. | +++ | 0.40 ± 0.03 | |
13 | 4-Nitrophenol | N.D. | +++ | 0.33 ± 0.17 | |
14 | BaP-4,5 (±) diol | N.D. | +++ | 0.28 ± 0.01 | |
15 | Quercetin | 0.005, 0.03, 0.02 | +++ | 0.22 ± 0.05 | |
16 | 9-OH BaP | N.D. | +++ | 0.17 ± 0.07 | |
17 | Estriol | 0.010, 0.03 | +++ | 0.15 ± 0.05 | |
18 | 4-OH-biphenyl | 0.01, 0.002, 0.008 | +++ | 0.07 ± 0.04 | |
19 | 3-OH BaP | 0.02, 0.02, 0.005 | 0.62 ± 0.01 | 0.06 ± 0.03 | |
20 | 17β-Estradiol | 0.002, 0.005 | 0.66 ± 0.01 | 0.05 ± 0.03 | |
21 | 16α-OH pregnenolone | 0.001, 0.004 | 0.02 ± 0.01 | 0.05 ± 0.03 | |
22 | 8-OH BaP | N.D. | 0.22 ± 0.04 | 0.03 ± 0.02 | |
23 | 2-OH BaP | N.D. | +++ | 0.03 ± 0.00 | |
24 | 17β-Ethynylestradiol | 0.009, N.D., 0.006 | +++ | 0.03 ± 0.01 | |
25 | Phenol red | 0.001, 0.006 | 0.07 ± 0.01 | N.D. | |
26 | Dinitrocatechol | N.D. | 0.52 ± 0.03 | N.D. | |
27 | Estrone | N.D. | 0.17 ± 0.01 | N.D. | |
28 | 4-OH estradiol | 0.003, N.D. | 0.05 ± 0.01 | N.D. | |
29 | Propofol | 0.002, 0.001 | +++ | N.D. | |
30 | BaP-7,8 (+) diol | N.D. | 0.52 ± 0.01 | N.D. | |
31 | BaP-7,8 (-) diol | N.D. | 0.57 ± 0.08 | N.D. | |
32 | Mycophenolic acid | N.D. | 0.05 ± 0.03 | N.D. | |
33 | Serotonin | N.D. | 0.15 ± 0.03 | N.D. | |
34 | Acetaminophen | N.D. | 0.03 ± 0.01 | N.D. | |
35 | Bisphenol A | N.D. | +++ | N.D. | |
36 | Bilirubin | N.D. | N.D. | N.D. | |
37 | Butylated hydroxytoluene | N.D. | 0.04 ± 0.00 | N.D. | |
38 | Butylated Hydroxyquinone | N.D. | 0.03 ± 0.00 | N.D. | |
39 | Buprenorphine | N.D. | 0.04 ± 0.00 | N.D. | |
40 | Epicatechin | N.D. | 0.65 ± 0.19 | N.D. |
N.D., not detectable (<0.01 nmol/min/mg protein).