Species (n) | Dose | Analyte | Cmax (S.D.)a | Tmax (Range) | AUCINF (S.D.)a | t1/2 (S.D.) | CLT (S.D.) | Vss (S.D.) |
---|---|---|---|---|---|---|---|---|
h | h | l/h | liters | |||||
Human (8) | 10 mg | BMS-204352 | 121 (57) | 0.1 (0.1, 0.1) | 184 (46) | 37 (14) | 64 (29) | 714 (527) |
Radioactivity | 208 (62) | 24 (16, 24) | 50,507 (18,182) | 259 (115) | 0.23 (0.11) | |||
Dogb(3) | 2 mg/kg | BMS-204352 | 2155 (411) | 0.1 (0.1, 0.1) | 9811 (881) | 16 (0.7) | 21 (2.0) | 41 (5) |
Radioactivity | 7026 (933) | 32 (24, 32) | 444,812 (54,764) | 158 (15) | 0.46 (0.01) | |||
Ratb(3) | 6 mg/kg | BMS-204352 | 1430 (498) | 0.1 (0.1, 0.1) | 1066 (206) | 2.3 (0.3) | 0.65 (0.12) | 1.6 (0.3) |
|
| Radioactivity | 2621 (245) | 3.0 (3.0, 6.0) | 48,804 (4447) | 22 (5.5) | 0.014 (0.003) |
|
↵a Units for Cmax: BMS-204352 ng/ml and radioactivity, ng-Eq/ml. Units for AUC: BMS-204352, ng · h/ml and radioactivity, ng-Eq · h/ml).
↵ b Portions of pharmacokinetics data in dogs and rats have been presented previously (Krishna et al., 2002d).