IC50 values of 4-MUG on the transport of [3H]E217ßG
Each value was calculated by fitting the data shown in Fig. 7. r represents the ratio of the contribution of the higher affinity component into the equations (see Materials and Methods). IC50High and IC50Low mean the IC50 value for the high-affinity site and for the low-affinity site, respectively. Values represent the obtained parameter ± computer calculated S.D.
Rat Mrp2 | Dog Mrp2 | |
|---|---|---|
| Single-site fitting | ||
| IC50 (μM) | 452 ± 28 | 585 ± 84 |
| AIC | –25.1 | –16.3 |
| Two-site fitting | ||
| r | 0.80 ± 0.24 | 0.42 ± 0.15 |
| IC50High (μM) | 400 ± 138 | 70.1 ± 51.8 |
| IC50Low (mM) | 2.00 ± 0.63 | 1.54 ± 0.16 |
| AIC | –15.6 | –18.7 |