Comparison of rates of N-deamination for sertraline and N-desmethylsertraline in MAO and human liver microsomes Substrate concentration used was 50 μM.
Enzyme System | Reaction Velocity | ||
|---|---|---|---|
| Sertraline | N-Desmethylsertraline | ||
| Pooled human liver microsomes (pmol/min/nmol P450) | 95.8 ± 8.2 | 29.5 ± 3.6 | |
| MAO-A (pmol/min/nmol MAO) | 6.04 ± 0.86 | 3.37 ± 0.76 | |
| MAO-B (pmol/min/nmol MAO) | 14.4 ± 0.8 | 8.88 ± 0.76 | |