Metabolites of [14C]SB-209247 (100 μmol/kg) in the bile of rats dosed i.v.
The data are expressed as mean percentage ± S.E.M. (n = 4) of the administered radioactivity. Metabolites were resolved by HPLC (Fig. 2A) and quantified with a radioactivity flow detector.
Collection | SB-209247 Glucuronide | SB-209247 Sulfoxide Glucuronide |
|---|---|---|
| h | ||
| 0-1 | 23.8 ± 4.0 | 12.0 ± 3.4 |
| 1-2 | 11.0 ± 2.3 | 5.5 ± 1.4 |
| 2-3 | 3.4 ± 0.9 | 1.0 ± 0.2 |