Dose | Cmax | AUCt | AUC∞ | tmax | t1/2 | CL/F | Vz/F | F* | ||
---|---|---|---|---|---|---|---|---|---|---|
μg/ml | μg · h/ml | h | l/h/kg | l/kg | % | |||||
10 μmol/kg | 0.0301 ± 0.0130 | 0.00617 ± 0.00229 | N.D. | 0.278 ± 0.192 | N.D. | N.D. | N.D. | — | ||
20 μmol/kg | 0.137 ± 0.059 | 0.0309 ± 0.0160 | 0.0518 | 0.222 ± 0.096 | 0.145a | 43.7a | 9.11a | 10.4 | ||
40 μmol/kg | 0.419 ± 0.293 | 0.100 ± 0.064 | 0.142 | 0.167 ± 0.000 | 0.174b | 33.7b | 8.48b | 14.3 | ||
80 μmol/kg | 4.45 ± 1.47 | 1.39 ± 0.52 | 1.39 ± 0.52 | 0.222 ± 0.096 | 0.144 ± 0.044 | 7.25 ± 3.14 | 1.41 ± 0.33 | 69.9 |
N.D., not determined; —, not calculated.
↵ a n = 1; b n = 2 (λz not estimated by linear regression in some cases).