Pharmacokinetic parameters of [13C]uracil obtained on the basis of 13CO2 concentration (Δ13C) in breath in DPD-deficient male dogs treated with BVU and normal male dogs after oral administration at 20 μmol/kg
Numbers in parentheses indicate the ratio relative to the control value. Values are mean ± S.D.
Group | Breath tmax | Breath Cmax | Breath AUCt | Breath t1/2 |
|---|---|---|---|---|
| min | ‰ | (‰ · min) × 103 | min | |
| Untreated control (n = 6) | 25.0 ± 12.3 | 57.3 ± 6.8 | 2.95 ± 0.87 | 17.3 ± 7.2 |
| 2 μmol/kg BVU (n = 3) | 80.0 ± 22.9 | 22.6 ± 1.4 (0.39) | 2.59 ± 0.20 (0.88) | 19.9 ± 13.9 (1.2) |
| 5 μmol/kg BVU (n = 3) | 85.0 ± 31.2 | 10.8 ± 3.2 (0.19) | 1.38 ± 0.63 (0.47) | 25.7 ± 17.4 (1.5) |
| 40 μmol/kg BVU (n = 3) | 80.0 ± 34.6 | 3.0 ± 1.1 (0.05) | 0.391 ± 0.227 (0.13) | 69.2 ± 91.6 (4.0) |