TABLE 7

Pharmacokinetic parameters of [13C]uracil obtained on the basis of blood concentrations of [13C]uracil in DPD-deficient male dogs treated with BVU and normal male dogs after intravenous administration at 20 μmol/kg

Numbers in parentheses indicate the ratio relative to the control value. Values are mean ± S.D. (n = 3).

Group
AUCt
AUC∞
t1/2
CL
Vz
μg · h/ml h l/h/kg l/kg
Untreated control 0.564 ± 0.070 0.580 ± 0.075 0.0917 ± 0.0183 3.94 ± 0.51 0.520 ± 0.087
0.5 μmol/kg BVU 0.766 ± 0.124 (1.4) 0.776 ± 0.114 (1.3) 0.122 ± 0.018 (1.3) 2.96 ± 0.45 0.511 ± 0.046
2 μmol/kg BVU 2.35 ± 0.30 (4.2) 2.37 ± 0.29 (4.1) 0.433 ± 0.083 (4.7) 0.964 ± 0.120 0.619 ± 0.146
40 μmol/kg BVU
7.25 ± 0.41 (13)
10.2 ± 0.8 (18)
2.10 ± 0.20 (23)
0.224 ± 0.017
0.661 ± 0.040