Pharmacokinetic parameters of [13C]uracil obtained on the basis of 13CO2 concentration (Δ13C) in breath in DPD-deficient male dogs treated with BVU and normal male dogs after intravenous administration at 20 μmol/kg
Numbers in parentheses indicate the ratio relative to the control value. Values are mean ± S.D. (n = 3).
Group | Breath tmax | Breath Cmax | Breath AUCt | Breath t1/2 |
|---|---|---|---|---|
| min | ‰ | (‰ · min) × 103 | min | |
| Untreated control | 15.0 ± 0.0 | 61.1 ± 9.5 | 2.38 ± 0.24 | 12.9 ± 4.0 |
| 0.5 μmol/kg BVU | 11.7 ± 5.8 | 44.8 ± 3.8 (0.73) | 2.46 ± 0.31 (1.0) | 13.6 ± 8.5 (1.1) |
| 2 μmol/kg BVU | 45.0 ± 0.0 | 22.7 ± 0.9 (0.37) | 1.98 ± 0.11 (0.83) | 24.9 ± 11.9 (1.9) |
| 40 μmol/kg BVU | 35.0 ± 8.6 | 2.65 ± 2.29 (0.04) | 0.175 ± 0.202 (0.07) | 18.7 ± 10.0 (1.4) |