TABLE 3

Pharmacokinetic parameters of SDN and nalbuphine after intravenous administration of SDN in sesame oil solution and of nalbuphine after intravenous administration of nalbuphine HCl to rats (n = 6; mean ± S.D.)

Parametersa
SDN
Nalbuphine (Formed from SDN)
Nalbuphine (from Nalbuphine HCl)
Cmax (μg/ml) 2.47 ± 0.54
Tmax (min) 19.17 ± 2.04
t1/2 (min) 9.74 ± 3.44 95.56 ± 34.83 107.00 ± 32.78
AUC0-∞ (μg · min/ml) 5.22 ± 3.82 322.30 ± 76.42 196.75 ± 30.38*
CL (l/min/kg) 6.28 ± 2.79 0.066 ± 0.015 0.116 ± 0.019*
Vd (l/kg)
91.45 ± 54.39
8.52 ± 1.62
17.43 ± 3.78*

  • CL, clearance.

  • ↵* P < 0.05 as compared with the nalbuphine data following intravenous administration of SDN.

  • ↵ a Assume F = 1 for SDN converted to nalbuphine after intravenous bolus of SDN.