TABLE 2

Levels of MeSO2-PCBs in the livers of rats, guinea pigs, and hamsters dosed with Kanechlor 500

Each value represents the mean ± S.E. for three to four animals.

Abbreviation
Structure
Levels (μg/g wet wt)
Rat
Guinea Pig
Hamster
2,5-Dichloro-substituted
    3′-49 3′-MeSO2-2,4,2′,5′-tetraCB 17 ± 2 60 ± 17 N.D.
    4′-49 4′-MeSO2-2,4,2′,5′-tetraCB 8 ± 2 N.D. N.D.
    3-70 3-MeSO2-2,5,3′,4′-tetraCB 50 ± 11 6 ± 2 6 ± 1
    4-70 4-MeSO2-2,5,3′,4′-tetraCB 41 ± 6 N.D. 20 ± 7
    3′-87 3′-MeSO2-2,3,4,2′,5′-pentaCB 32 ± 8 160 ± 44 7 ± 2
    4′-87 4′-MeSO2-2,3,4,2′,5′-pentaCB 27 ± 4 70 ± 7 5 ± 2
    3′-101 3′-MeSO2-2,4,5,2′,5′-pentaCB 43 ± 10 32 ± 4 42 ± 10
    4′-101 4′-MeSO2-2,4,5,2′,5′-pentaCB 48 ± 5 5 ± 2 25 ± 5
    3′-141 3′-MeSO2-2,3,4,5,2′,5′-hexaCB 2 ± 1 33 ± 4 N.D.
    4′-141 4′-MeSO2-2,3,4,5,2′,5′-hexaCB 3 ± 1 N.D. N.D.
Total 271 ± 44 366 ± 72 105 ± 16*
2,3,6-Trichloro-substituted
    5-64 5-MeSO2-2,3,6,4′-tetraCB 5 ± 1 130 ± 26 N.D.
    4-64 4-MeSO2-2,3,6,4′-tetraCB 6 ± 1 N.D. N.D.
    5-91 5-MeSO2-2,3,6,2′4′-pentaCB 4 ± 1 77 ± 19 15 ± 4
    4-91 4-MeSO2-2,3,6,2′,4′-pentaCB 2 ± 1 N.D. 9 ± 2
    5-110 5-MeSO2-2,3,6,3′,4′-pentaCB N.D. 6 ± 2 N.D.
    4-110 4-MeSO2-2,3,6,3′,4′-pentaCB 42 ± 9 N.D. 5 ± 3
    5′-132 5′-MeSO2-2,3,4,2′,3′,6′-hexaCB 20 ± 4 146 ± 42 2 ± 1
    4′-132 4′-MeSO2-2,3,4,2′,3′,6′-hexaCB 21 ± 3 N.D. N.D.
    5′-149 5′-MeSO2-2,4,5,2′,3′,6′-hexaCB 14 ± 2 110 ± 21 2 ± 1
    4′-149 4′-MeSO2-2,4,5,2′,3′,6′-hexaCB 17 ± 3 N.D. 3 ± 1
Total 131 ± 20 469 ± 82 36 ± 8
Sum meta-MeSO2-CBs 187 ± 50 760 ± 93* 74 ± 16
Sum para-MeSO2-CBs 215 ± 71 75 ± 13.3 67 ± 11
Total MeSO2-CBs 402 ± 90 835 ± 184* 141 ± 42*
Ratio
meta-/para-MeSO2-CBs 0.87 10.1 1.10
2,5-/2,3,6-chloro substituted
2.07
0.78
2.92

  • N.D., not detected (<0.1 μg/g).

  • ↵* Significantly different from rats, P < 0.01 (Student's t test).