Determination of activities of recombinant UGTs, human liver, and jejunum microsomes (positive control)
Each value represents the mean of duplicate determinations.
Source of UGT | Probe Substrate | UGT Activity |
|---|---|---|
| nmol/min/mg protein | ||
| UGT1A1 | 7-HFC | 1.49 |
| UGT1A3 | 7-HFC | 2.21 |
| UGT1A4 | Trifluoperazine | 1.43 |
| UGT1A6 | 7-HFC | 4.42 |
| UGT1A7 | 7-HFC | 12.6 |
| UGT1A8 | 7-HFC | 0.66 |
| UGT1A9 | 7-HFC | 6.49 |
| UGT1A10 | 7-HFC | 0.24 |
| UGT2B4 | 7-HFC | 0.47 |
| UGT2B7 | 7-HFC | 3.69 |
| UGT2B15 | 7-HFC | 3.73 |
| UGT2B17 | 7-HFC | 0.11 |
| Human liver | 7-HFC | 62.2 |
| Human jejunum | 7-HFC | 19.1 |