Inhibition of human liver microsomal amodiaquine N-deethylase activity by montelukast at varying microsomal protein concentrations
Microsomal Protein Concentration | IC50 (Mean ± S.E.) | IC90 |
|---|---|---|
| μM | μM | |
| 0.025 mg/ml | 0.020 ± 0.002 | 0.23 |
| 0.1 mg/ml | 0.072 ± 0.005 | 0.64 |
| 0.3 mg/ml | 0.18 ± 0.01 | 1.7 |
| 1.0 mg/ml | 0.71 ± 0.06 | 6.5 |
| 2.0 mg/ml | 2.0 ± 0.1 | 18 |