In Vivo Inhibitor Concentration Available to the Enzyme | Equation Used to Estimate the in Vivo Inhibitor Concentration ([I]in vivo) Available to the Enzyme | Magnitude of Drug Interaction (Fold Increase in Exposure) |
---|---|---|
Systemic total Cmax | [I]in vivo = Cmax | 112 |
Systemic free Cmax | [I]in vivo = fu · Cmax | 2.1 |
Estimated total portal Cmax | [I]in vivo = Cmax + ka · Fa · D/Qh | 119 |
Estimated free portal Cmax | [I]in vivo = fu · (Cmax + ka · Fa · D/Qh) | 2.2 |
AUC, area under the curve.