TABLE 1

Intrinsic clearance data for metabolism of compounds by rat hepatocytes

Data are the mean of two experiments. Average coefficient of variation of duplicate data is 25%.


Compound

CLint/μl/min/106 Cells
Data with 0.2% BSA Present
Data with 0.2% BSA and Inhibitors Present
Data without BSA but with Inhibitors Present
2-Ethoxybenzamide 19.4 <1 1.7
Albendazole 2.5 0.8 1.2
Astemizole 8.3 2.5 1.1
Betaxolol 6.8 0.6 0.9
Bumetanide 2.1 <1 1.3
Cerivastatin <1 <1 <1
Clozapine 22 2.3 2.7
Diazepam 3.2 <1 <1
Glyburide <1 <1 3.2
Indapamide 1.7 0.4 0.8
Isradipine 7.5 1.1 1.1
Metoprolol 6.2 <1 <1
Metyrapone 5.5 4.5 5.5
Omeprazole 7.4 <1 <1
Oxaprozin 3.1 <1 1.1
Propranolol 32 0.9 2.6
Verapamil
20
4.2
2.8