Pharmacokinetic Parameters | Dose | ||||
---|---|---|---|---|---|
1 mg/kg | 2 mg/kg | 5 mg/kg | |||
AUCplasma (mg × min/ml) | 8.71 ± 1.50 | 18.1 ± 8.51 | 50.5 ± 5.96 | ||
CL (l/min/kg) | 0.12 ± 0.02 | 0.14 ± 0.02 | 0.10 ± 0.02 | ||
Vss (l/kg) | 12.5 ± 3.28 | 14.6 ± 3.54 | 8.43 ± 1.72 | ||
AUCbrain (mg × min/ml) | 14.7 ± 1.5 | 16.8 ± 2.3 | 32.5 ± 4.2 | ||
KD,brain | 1.75 ± 0.59 | 0.93 ± 0.29 | 0.63 ± 0.10 |
KD,brain, AUCbrain divided by AUCplasma.