Metabolite Identification | HLM | CYP2C9 | ||||
---|---|---|---|---|---|---|
Capsaicin | Nonivamide | Capsaicin | Nonivamide | |||
% of total metabolites | % of total metabolites | |||||
Macrocycle (M1) | 22 ± 4 | N.D. | 34 ± 3 | N.D. | ||
ω-OH (M2) | 18 ± 4 | 24 ± 4 | 1 ± 0.2 | 0.8 ± 0.1 | ||
ω-1-OH (M3) | 8 ± 2 | N.D. | <0.1 | N.D. | ||
Diene or alkene (M4) | 28 ± 5 | 4 ± 1 | 63 ± 5 | 5 ± 2 | ||
Others (M5—M9) | 28 ± 14 | 71 ± 4 | <2 | 95 ± 4 |
HLM, human liver microsomes; N.D., not detected.