TABLE 1

Physical-chemical properties of statins tested in the present study


Name

Structure

Molecular Weight

ClogPa

pKaa
Atorvastain acid Embedded Image
558.2 4.22 4.30
Atorvastatin lactone 540.6 4.31 10.5
Lovastatin acid 422.5 3.71 4.31
Lovastatin lactone 404.5 4.07 13.5
Pravastatin 424.3 1.44 4.31
Simvastatin lactone 418.6 4.41 13.6
Simvastatin acid
436.6
4.05
4.31
  • a Values were obtained from SciFinder Database