Parameter | Furosemide Alone | With Bucolome | ||||
---|---|---|---|---|---|---|
10 mg/kg | 15 mg/kg | 20 mg/kg | ||||
AUC (μg/ml · min) | 563 ± 82 | 572 ± 31 | 414 ± 47* | 336 ± 91** | ||
CLtot (ml/min/kg) | 3.61 ± 0.52 | 3.51 ± 0.19 | 4.87 ± 0.52 | 6.24 ± 1.54* | ||
CLr (ml/min/kg) | 1.08 ± 0.16 | 1.42 ± 0.25 | 2.11 ± 0.21** | 2.67 ± 0.42** | ||
Vdss (ml/kg) | 75.7 ± 6.0 | 75.1 ± 1.3 | 92.1 ± 5.6** | 112 ± 7** | ||
t1/2β (min) | 44.7 ± 12.7 | 33.6 ± 3.7 | 35.7 ± 9.6 | 29.4 ± 4.5 | ||
fb (%) | 1.28 ± 0.36 | 1.41 ± 0.72 | 1.99 ± 0.76 | 3.03 ± 0.57** |