TABLE 3
Percentage of dose of [3H]caspofungin in rat livers in situ and in vivo pre- and postwash with perfusate containing albumin
For the in situ group, rat livers were perfused with [3H]caspofungin (10 μg/ml) in a recirculated mode for 60 min. For the in vivo group, rats received an intravenous bolus of [3H]caspofungin (2 mg/kg) and livers were sampled 0.5 and 24 h postdosing. For the washout, livers were perfused in a single-pass mode for 60 min with the perfusate containing a high concentration of albumin (4%). Data shown are the mean ± S.D. (n = 3).