Major factors responsible for the individual variability in P450 induction by drugs
Factors | Consequences |
|---|---|
| Variable transport and metabolism of inducers in vivo | Variable tissue and intracellular inducer concentrations resulting in different extent of induction |
| Genetic variations of P450 genes and their regulatory regions | Altered pattern of induction |
| Genetic variations of receptors and regulatory proteins required for induction | Altered pattern of induction |
| Physiological factors: disease states (inflammation, infection, and liver dysfunction), gender, hormonal homeostasis | Altered response to inducers |
| Environmental factors: dietary components, environmental contaminants | Altered response to inducers |