TABLE 1

Cumulative accumulation of lysozyme in kidneys (indicated by 123I) within 24 h after subcutaneous or intravenous injections of 2 MBq of 123I-TC-lysozyme combined with different doses of unlabeled lysozyme in healthy and Adriamycin-nephrotic rats

Data represent the mean ± S.E.M. for n = 4 in all cases. The extent of lysozyme accumulation was compared between subcutaneous and intravenous dose for healthy and diseased animals (p < 0.01) and between tracer dose of 123I-TC-lysozyme alone and tracer dose combined with 100 or 500 mg/kg unlabeled lysozyme (* p < 0.05, ** p < 0.01, and *** p < 0.001).


Dose of Unlabeled Lysozyme (mg/kg)

Healthy Rats

Adriamycin-Nephrotic Rats
Subcutaneous
Intravenous
Subcutaneous
Intravenous
0 89 ± 4.4 88 ± 1.9 59 ± 7.9 61 ± 9
100 75 ± 4.7 61 ± 3.6*** 44 ± 7.8 34 ± 5.9*
500
63 ± 3.5**
35 ± 5.7†.***
26 ± 6.5*
9 ± 7.8**