Pharmacokinetic parameters (two-compartment model) derived from plasma captopril concentration-time curves after a single dose (equivalent to 1 mg/kg of captopril) of captopril-lysozyme
Parameters | Values (mean ± S.E.M.) |
|---|---|
| Ka (per h) | 0.45 ± 0.06 |
| F | 0.71 ± 0.07 |
| Vss (ml/kg) | 477 ± 89 |
| CL (ml/kg/h) | 150 ± 14 |
| t1/2 α (h) | 0.46 ± 0.12 |
| t1/2 β (h) | 3.32 ± 0.23 |
Ka, absorption rate constant; F, bioavailability; Vss, volume of distribution at steady-state level; CL, plasma clearance; t1/2 α, distribution half-life; t1/2 β, elimination half-life.