P450 | Isoform Marker Activity | Correlation Coefficient (r) | ||
---|---|---|---|---|
M4 | M2 | |||
1A2 | Phenacetin O-deethylation | 0.11 | 0.20 | |
2A6 | Coumarin 7-hydroxylation | 0.05 | 0.09 | |
2B6 | (S)-Mephenytoin N-demethylation | 0.21 | 0.12 | |
2C8 | Paclitaxel 6α-hydroxylation | 0.20 | 0.17 | |
2C9 | Tolbutamide 4′-hydroxylation | 0.84* | 0.89* | |
2C19 | (S)-Mephenytoin 4′-hydroxylation | 0.16 | 0.31 | |
2D6 | Bufuralol 1′-hydroxylation | 0.09 | 0.27 | |
2E1 | Chlorzoxazone 6-hydroxylation | 0.23 | 0.12 | |
3A4 | Testosterone 6β-hydroxylation | 0.31 | 0.36 | |
4A | Lauric acid 12-hydroxylation | 0.18 | 0.08 |
↵* Significantly correlated (p < 0.005). Correlation study was carried out using human microsomes prepared from 12 different donors and represents the average of two determinations