Pharmacokinetic parameters of propafenone after oral administration at 3, 10, 20, and 45 mg/kg to female rats
Dose | |||||||
|---|---|---|---|---|---|---|---|
| 3 | 10 | 20 | 45 | ||||
| mg/kg | |||||||
| Cmax (ng/ml) | 55.3a | 134 | 231 | 706 | |||
| Tmax (h) | 0.5 | 0.5 | 0.25 | 0.25 | |||
| t1/2 (h) | 0.584 | 0.584 | 0.780 | 0.859 | |||
| MRT (h) | 1.17 | 1.33 | 1.74 | 1.92 | |||
| AUC (ng · h/ml) | 62.8 | 214 | 377 | 1502 | |||
| CL/F (l/h/kg) | 47.8 | 46.7 | 53.1 | 30.0 | |||
↵ a Derived from the average of plasma concentrations of three animals