TABLE 6

Depletion rate constant of propafenone in human hepatocytes with or without plasma, HSA and AGP

Initial Concentration	k_dep
Initial Concentration		Buffer^a	Plasma	HSA	AGP
	min^-1
0.05 μM	0.0892 ± 0.0523^b	0.00910 ± 0.00803^b	0.0201^c	0.00336^c
0.2 μM	0.0522 ± 0.0338	0.00999 ± 0.00783	0.0119	0.00621
1 μM	0.0222 ± 0.0093	0.00258 ± 0.00111	0.00427	0.00289
5 μM	0.00774 ± 0.00516	0.00120 ± 0.00022	0.000773	0.00257

↵ a Without plasma
↵ b Mean ± S.D. of hepatocytes from three donors (lot no. 83, 86, and RNG)
↵ c Mean of hepatocytes from two donors (lot no. 86 and RNG)