TABLE 8

Protein binding parameters for propafenone in rat and human plasma



Estimated Values ± S.D.a

Rats
Humans
Bmax1 (μM) 1.43 ± 0.35 8.63 ± 2.49
Kd1 (μM) 0.00759 ± 0.00295 0.664 ± 0.253
Bmax2 (μM) 762 ± 339 1084 ± 147
Kd2 (μM)
83.9 ± 43.5
322 ± 84.7
  • a Derived from fitting the mean values of three experiments to eq. 4