Detection of novel pioglitazone metabolites in incubations with liver microsomes and freshly isolated hepatocytes
Metabolite | Liver Microsomes | Freshly Isolated Hepatocytes | |||||
|---|---|---|---|---|---|---|---|
| Rat | Human | Rat | Human | ||||
| relative abundance | |||||||
| M-A | +(1.7%) | +(2.5%) | +(0.5%) | N.D. | |||
| M-B | +(1.8%) | +(0.2%) | +(0.3%) | N.D. | |||
+, metabolite detected; N.D., not detected; %, the relative abundance of the metabolite peak area compared to the peak area of parent.