TABLE 2

Kinetic parameters of wild-type and L48V UGT1A 4 for clozapine

Allele	V_max ^a	K_m ^b	V_max/K_m
	pmol/min/mg	μM	μmol/min/mg
Wild type	1205 ± 168.0	49.18 ± 13.9	25.4 ± 4.80
L48V	1315 ± 246.8	25.41 ± 5.05	52.7 ± 13.1^c

↵ a V_max, maximum velocity.
↵ b K_m, Michaelis constant.
↵ c Significantly different from the wild type (*P < 0.05). P value was obtained by using the t test.