TABLE 1

Presence of clofarabine and radioactive metabolites in radiochromatograms of rat plasma, tissue, and excreta and in rat, dog, and human hepatocytes A summary of radioactive peak regions observed (marked with x) in the chromatograms of the evaluated matrices from the in vitro and in vivo studies is given.

Peak Name
Retention Time
Rat Hepatocytes
Dog Hepatocytes
Human Hepatocytes
Rat Plasma
Rat Tissue
Rat Urine
Rat Feces
min
P1 2–3 x x x
P2 3–4 x x
P3 4–5 x x
P4 6–7 x x x
P5 8–9 x x x x
P6 12–15 x
P7 15–17 x x x
P8 17–19 x x x x x
P9 19–23 x x x x x x
P10 23–26 x x
P11 25–29 x x x x x
P12 29–30 x x x x x
P13 30–32 x x x x
P14 32–34 x x x x x
P15a 36–39 x x x x x x x
P16 37–41 x x x x x
P17
42–46
x
x

  • ↵ a Denotes that peak is parent clofarabine