Metabolite profiles of rat, dog, and human hepatocyte samples following 10 μM incubation of [14C]clofarabine for 6 h (percentage radioactivity in the chromatogram)
Species | P6 | P7 | P8 | P9 | P10 | P11 | P12 | P13 | P14 | P15 | P16 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rat | N.D. | 0.4 | 0.4 | 0.4 | 0.7 | 1.2 | 0.9 | 0.1 | 0.5 | 95.8 | 0.2 |
| Dog | 0.4 | 0.5 | N.D. | 0.6 | N.D. | 2.5 | 0.8 | N.D. | 0.4 | 94.8 | N.D. |
| Human | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. | 0.2 | 99.8 | N.D. |
N.D., not detected.