TABLE 3

Inhibitory effect of genistein and apigenin on glucuronidation of raloxifene by human and rat jejunal microsomes and Caco-2 cell lysate Raloxifene (4.34 μM) and inhibitor (0∼100 μM genistein or apigenin) were added to the microsomes with cofactors as described under Materials and Methods. Apparent 50% inhibitory concentration (IC₅₀) values were obtained by nonlinear regression of the data presented in Fig. 7 using SigmaPlot.