TABLE 1

Pharmacokinetic parameters of doxorubicin in plasma of control versus LPS-treated mice following a 5 mg/kg i.v. dose (mean ± S.E.)

Control
LPS
AUC0-24, (ng·h)/mla 609.0 ± 42.0 771.6 ± 40.7*
CLt, ml/hb 139.7 128.9
fu, plasmac 0.35 ± 0.004 0.67 ± 0.006*
t1/2(β), hd 18.3 17.8
Vss, mle 3249 2531
CLr, ml/hf
4.05 ± 0.28
10.3 ± 0.54*

  • ↵* Significantly different from controls, p < 0.05 (Z test)

  • ↵ a Mean and S.E. of AUC0-24 calculated using the method of Bailer (1988)

  • ↵ b CLt calculated by compartmental analysis as Dose/AUC0-8

  • ↵ c Determined at plasma concentration 100 ng/ml

  • ↵ d t1/2(β) calculated as 0.693/β

  • ↵ e Vss calculated by compartmental analysis as V1 + V2

  • ↵ f CLr calculated by ΣXu24/AUC24