Pharmacokinetic parameters of doxorubicin metabolites in plasma of control versus LPS-treated mice following administration of doxorubicin at a 5 mg/kg i.v. dose (mean ± S.E.)
M2 (7-Deoxy-doxorubicinone) | M3 (7-Deoxy-doxorubicinolone) | |||||
|---|---|---|---|---|---|---|
| Control | LPS | Control | LPS | |||
| AUC0-12, (ng · h)/ml | 53.0 ± 8.6 | 263.3 ± 62.8* | 131.6 ± 28.3 | 98.5 ± 14.7 | ||
| CLr, ml/h | 0.31 ± 0.05 | 0.35 ± 0.08 | 0.25 ± 0.05 | 0.53 ± 0.08 | ||
↵* Significantly different from controls, p < 0.05 (Z test)