TABLE 3

Relative EROD activity and levels of CYP1A1 and CYP1A2 mRNA in dog hepatocytes incubated for 48 h with varying concentrations of compound I

Donor Number
Treatment
Concentration
CYP1A2 RNAa (Relative Amount)
CYP1A1 RNAa (Relative Amount)
EROD Activitya (Relative Amount)
μM
1 BNF 25 15.4b 22.6b 7.0b
Compound I 0.2 0.8 0.5b 0.9
Compound I 2 0.3b 0.1b 0.9
Compound I 20 0.4b 0.1b 0.8
2 BNF 25 2.4b 8.1b 4.4b
Compound I 0.2 0.9 1.5 0.8
Compound I 2 0.5b 0.5 0.7
Compound I
20
0.4b
0.5
0.6

  • ↵ a The values are expressed relative to solvent control incubations.

  • ↵ b Statistically significant difference relative to solvent control (P < 0.05).