Sample size estimates required to see a 30% change in the oral clearance of dextromethorphan, DTM/DT serum concentration ratios at 3, 4, 6, and 8 h, DTM/DTAUC ratio, and UMR with 80% power
Parameter | Study Design | ||
|---|---|---|---|
| Crossover | Cross-sectional | ||
| Oral clearance (DTM/DT serum concentration ratio) | 14 | 60 | |
| 3 h | 42 | 410 | |
| 4 h | 50 | 620 | |
| 6 h | 46 | 390 | |
| 8 h | 26 | 660 | |
| DTM/DT AUC ratio | 34 | 250 | |
| UMR | 56 | 524 | |