TABLE 1

Details on the nine CYP2D6 substrates investigated in the drug-drug interaction studies

CYP2D6 Substrate
Number of Studies Predicted
fmCYP2D6
References
From PM Dataa
 From Regression Analysisb
Desipramine 11(5)c 0.877 0.799 Brosen and Gram (1988)
Encainide 2 0.857 0.814 Funck-Brentano et al. (1989)
Flecainide 1 0.412 0.748 Mikus et al. (1989)
Imipramine 7 0.457 0.549 Brosen and Gram (1988)
Metoprolol 12 0.828 0.695 Silas et al. (1985)
Mexiletine 1 0.493 0.247 Turgeon et al. (1991)
Propafenone 2 0.763 0.540 Siddoway et al. (1987)
Propranolol 9 0.367 0.579 Raghuram et al. (1984)
Tolterodine
1
0.942
0.891
Brynne et al. (1998)

  • ↵ a Using eq. 11

  • ↵ b Using eq. 6

  • ↵ c Number of studies measuring desipramine after imipramine dosing