Effects of NICmAb311 dose on nicotine binding in serum
Values are the mean ± S.D., except for unbound nicotine concentrations in the NICmAb groups, which show only the means because there were just two animals per group. Values for Nic-IgG, taken from the experiment illustrated in Table 1, are shown for comparison. Corresponding total serum and brain nicotine concentrations are shown in Fig. 3. There was a significant correlation between NICmAb311 dose and both the percentage of nicotine bound (r = 0.93; p < 0.01) and the unbound nicotine concentration in serum (r = 0.98; p < 0.05).
Treatment | Dose | Nicotine Bound | Unbound Nicotine |
|---|---|---|---|
| mg/kg | % | ng/ml | |
| Control-IgG | 160 | 32 ± 8 | 18 ± 2 |
| NICmAb311 | 10 | 95.0 | 10.1 |
| 20 | 97.3 | 8.5 | |
| 40 | 98.9 | 5.0 | |
| 80 | 99.5 | 3.1 | |
| 160 | 99.7 | 2.2 | |
| Nic-IgG | 10 | 99.5 ± 0.1 | 2.7 ± 0.7 |