TABLE 3

Noncompartmental pharmacokinetic parameter estimates for nicotine in rats pretreated with NICmAb311 or control-IgG

Rats received a single i.v. bolus dose of 0.1 mg/kg nicotine. NICmAb311 substantially reduced the Vd,ss, decreased Clt, and increased the terminal half-life.

Treatment
Cmax
AUC
Vd,ss
Clt
t1/2
ng/ml h · ng/ml l/kg l/h · kg h
Control-IgG 29 ± 12 48 ± 21 3.48 ± 1.24 2.15 ± 0.60 1.1 ± 0.2
NICmAb311
144 ± 33**
473 ± 120**
0.64 ± 0.10**
0.22 ± 0.05**
2.5 ± 0.3***

  • ↵** p < 0.01, *** p < 0.001 compared with controls.