Microsomal-free fractions (% free) of inactivators at 0.2 mg/ml microsomal protein at 37°C Values are mean (S.D.), n = 3 incubations.
Inactivator | Nominal Concentration | % Free |
|---|---|---|
| μM | ||
| Amprenavir | 0.5 | 95 (3) |
| 5 | 105 (2) | |
| Diclofenac | 0.5 | 53 (6) |
| 5 | 110 (16) | |
| Diltiazem | 0.5 | 112 (8) |
| 5 | 112 (6) | |
| Erythromycin | 0.5 | 103 (4) |
| 5 | 85 (5) | |
| Raloxifene | 0.5 | 15 (4) |
| 5 | 23 (2) | |
| Troleandomycin | 0.5 | 103 (10) |
|
| 5 | 93 (6) |