The effect of coincubation with inhibitor and 1-h preincubation with inactivator on CYP3A activities in cryopreserved human hepatocytes Values are mean (S.D.), n = 3 incubations.
Name | Coincubationa | Percentage of Control without Inhibitor | Preincubationb | Percentage of Control without Inhibitor |
|---|---|---|---|---|
| μM | μM | |||
| Amprenavir | 2.5 | 100 (3) | 1 | 46 (2) |
| Diclofenac | 50 | 97 (4) | 100 | 102 (4) |
| Diltiazem | 1 | 95 (10) | 1 | 75 (4) |
| Erythromycin | 10 | 97 (10) | 10 | 65 (11) |
| Raloxifene | 5 | 105 (4) | 5 | 48 (2) |
| Troleandomycin | 2.5 | 99 (4) | 1.5 | 57 (7) |
| Ketoconazole | 2 | 19 (1) |
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