TABLE 1

Pharmacokinetic parameters estimated for midazolam and cyclosporin A in CYP3A4 transgenic and wild-type mice

Mice received midazolam (30 mg/kg) or cyclosporin A (20 mg/kg) by intravenous administration. Values represent the mean ± S.E.

Wild-type
Transgenic
Midazolam
    AUC (μg · h ml-1) 11.7 ± 0.46 5.45 ± 0.21**
    CL (ml · h-1 kg-1) 2554 ± 99.7 5500 ± 216**
    t1/2 (h) 0.71 ± 0.04 0.45 ± 0.02*
Cyclosporin A
    AUC (μg · h ml-1) 35.8 ± 0.53 24.3 ± 0.66**
    CL (ml · h-1 kg-1) 558 ± 8.24 822 ± 22.3**
    t1/2 (h)
3.80 ± 0.46
2.89 ± 0.31

  • ↵* P < 0.05, ** P < 0.01, comparing wild-type and CYP3A4 transgenic mice.