Midazolam 1′-hydroxylase activities (pmol/mg/min) and fold-induction by rifampicin
Activities ± S.E.M. | Fold-Induction | 95% CI for Ratio | ||||
|---|---|---|---|---|---|---|
| HH1114 | Control-single | 99.7 ± 1.2 | Single | Cassette | ||
| Control-cassette | 111.9 ± 4.9 | |||||
| Rifampicin-single | 399.1 ± 13.2 | 4.0 ± 0.1 | 4.6 ± 0.5 | [1.0, 1.4] | ||
| Rifampicin-cassette | 520.7 ± 51.4 | |||||
| HH1119 | Control-single | 100.3 ± 4.6 | Single | Cassette | ||
| Control-cassette | 101.0 ± 2.8 | |||||
| Rifampicin-single | 408.8 ± 12.5 | 4.1 ± 0.1 | 4.7 ± 0.1 | [1.0, 1.3] | ||
| Rifampicin-cassette | 479.0 ± 9.7 | |||||
| HH1148 | Control-single | 48.2 ± 3.0 | Single | Cassette | ||
| Control-cassette | 47.7 ± 6.5 | |||||
| Rifampicin-single | 323.0 ± 22.7 | 6.7 ± 0.5 | 7.5 ± 0.8 | [0.7, 1.8] | ||
| Rifampicin-cassette | 357.4 ± 40.5 | |||||
| IVT | Control-single | 60.5 ± 3.1 | Single | Cassette | ||
| Control-cassette | 76.7 ± 4.4 | |||||
| Rifampicin-single | 215.6 ± 5.4 | 3.6 ± 0.1 | 3.7 ± 0.1 | [0.9, 1.3] | ||
|
| Rifampicin-cassette | 285.1 ± 9.6 |
|
|
| |