Diclofenac 4′-hydroxylase activities (pmol/mg/min) and fold-induction by rifampicin
Activities ± S.E.M. | Fold-Induction | 95% CI for Ratio | ||||
|---|---|---|---|---|---|---|
| HH1114 | Control-single | 27.9 ± 3.6 | Single | Cassette | ||
| Control-cassette | 35.2 ± 3.7 | |||||
| Rifampicin-single | 58.6 ± 8.6 | 2.1 ± 0.3 | 1.9 ± 0.1 | [0.5, 1.5] | ||
| Rifampicin-cassette | 65.3 ± 4.7 | |||||
| HH1119 | Control-single | 12.2 ± 0.7 | Single | Cassette | ||
| Control-cassette | 14.9 ± 0.7 | |||||
| Rifampicin-single | 26.7 ± 3.8 | 2.2 ± 0.3 | 1.5 ± 0.0 | [0.5, 1.0] | ||
| Rifampicin-cassette | 22.5 ± 0.3 | |||||
| HH1148 | Control-single | 15.0 ± 0.4 | Single | Cassette | ||
| Control-cassette | 13.0 ± 1.1 | |||||
| Rifampicin-single | 51.1 ± 1.6 | 3.4 ± 0.1 | 2.9 ± 0.7 | [0.6, 1.2] | ||
| Rifampicin-cassette | 38.0 ± 8.9 | |||||
| IVT | Control-single | 13.6 ± 1.0 | Single | Cassette | ||
| Control-cassette | 14.0 ± 1.8 | |||||
| Rifampicin-single | 39.5 ± 1.4 | 2.9 ± 0.1 | 2.0 ± 0.3 | [0.4, 1.1] | ||
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| Rifampicin-cassette | 28.3 ± 4.1 |
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