Sample | P450R Activity | Doxorubicin Reduction | |
---|---|---|---|
nmol/min/mg microsomal protein | |||
Rat liver microsomes | |||
– Carbon monoxide | 253 ± 13 | 11.0 ± 0.4 | |
+ Carbon monoxide | 274 ± 3 | 7.0 ± 0.8** | |
Human liver microsomes | |||
– Carbon monoxide | 103 ± 2 | 4.8 ± 0.3 | |
+ Carbon monoxide | 101 ± 9 | 6.1 ± 0.7** |
↵** Significantly different (p ≤ 0.01) from activity in the absence of carbon monoxide, based on Student's t test