TABLE 2

Estimated betamethasone pharmacokinetic parameters after administration of two prodrug formulations

Parameter	Estimate	CV (%)^a
ka_BMp (1/day)	60.6	9.19
ka_Bma (1/day)	1.25	5.36
V_c/F_BMp (1/kg)	1.10	3.57
V_c/F_BMa (1/kg)	1.77	12.2
k_e1 (1/day)	4.21	3.72
t_1/2ka_BMp (h)	0.275^b	9.19
t_1/2ka_BMa (h)	13.3^b	5.36
t_1/2k_el (h)	3.95^b	3.72
% F_BMa/F_BMp	62.3^b	12.1

↵ a Coefficient of variation of the estimate, not reflective of inter-animal variability
↵ b Secondary parameters